Tom Hanson (Johnny Depp) has just graduated from the police academy when he gets into trouble. He is reassigned to the undercover unit 'Jump Street-Capell', which deals with juvenile delinquents. There, Hanson must infiltrate a high school as a student to expose young offenders. Meanwhile, he helps Kenneth Wreckerle, a student who is bullied by a gang and has become addicted to drugs, find a place in a drug rehabilitation center.
The young officers from 'Jump Street Chapel' have two new cases underway: Judy Hoffs is dealing with a Polish exchange student, while the rest of the team is investigating the theft of a used car. Captain Jenko believes the thieves might be in an auto shop class at Northside High School. So, Hanson goes undercover at the school to get to the bottom of the matter...
Tom Hanson (Johnny Depp) is once again undercover at a high school. This time he is supposed to catch a burglar who leaves a rose on the English teacher's desk after each break-in. Jeffery Stone, the black sheep from a wealthy family, is regarded as the main suspect and is arrested. However, after he is released on bail, he finds the real culprit: the janitor.
A 16-year-old girl is found dead after a party at West Chadway High School. Before her death, she was raped by three men. To investigate more effectively, Captain Jenko sends Hanson (Johnny Depp) and Pennhall as students to Chadway High. The two quickly discover that the three main suspects are also actively smuggling drugs. However, the situation becomes complicated when the brother of the deceased girl intervenes in the police investigations, seeking revenge.
At Sacred Heart High School, a strange series of fires occur. Officer Judy Hoffs goes undercover as a student to search for clues. Even when someone is arrested as the main suspect, Hoffs remains skeptical about their guilt. At a school dance, Doug, Hanson, Ioki, and Hoffs are also present to ensure the safety of the students in case of a fire. The situation becomes critical when Doug asks a girl to dance, who then ignites the gasoline-soaked party decorations...
After Captain Jenko dies, the Jump Street team is temporarily disbanded. However, since the mayor values their work, he appoints Captain Fuller as the new head. Fuller sends Hanson (Johnny Depp) and his colleague Hoffs undercover to Grant High School. There they encounter the principal and the leader of the 'Bloods' gang, Brooks. Brooks threatens to kill the principal and takes control of the school. To release everyone, he demands 20 pizzas. Finally, he takes Hoffs hostage and demands an escape vehicle.
Penhall and Hanson (Johnny Depp) are tasked with quickly bringing two teenagers home. The teens are about to spend $12,000 that they stole from robbers. Meanwhile, Hoffs and Ioki need to retrieve a female student from the street. They discover that the girl only wants to pass on security codes that she got for a friend.
Tom Hanson (Johnny Depp) and Doug Penhall are working undercover as brothers at a college to investigate young drug dealers. There, Hanson is asked by student Diane Nelson to kill her father, as she believes him to be a criminal. It later turns out that the police chief has been abusing his daughter for years. During an attempted arrest, Hanson shoots at Nelson and is briefly arrested but released after the situation is clarified.
Hoagy, an 18-year-old from a wealthy but not so great family, is supposed to start a career. Instead, he gets involved in illegal businesses by lending money at extremely high interest rates. The Jump Street team is called in and quickly gets integrated into the school quiz team. On Hanson (played by Johnny Depp), who is in Davy's team, tough guys are set. Hanson's team loses, and to keep the cover from blowing, Fuller has to block Hanson's credit card. Hoagy is in a bind.
Penhall goes undercover in a college baseball team because the FBI believes that the star player Johnny Hartman might be kidnapped. After some time, the 'Jump Street' team finds out that Johnny's father is actually the target of the kidnapping. He is a key witness in a mafia trial and is in great danger, but mainly worries about his son's safety.
Penhall and Hoffs must go undercover in a modeling agency that allegedly lures minors into the porn business and introduces them to drugs. Captain Fuller uncovers more dubious activities involving youth. His son Kip has fallen under the spell of a guru. Kip believes that humanity can only be saved if everyone eats grains.
Tom Hanson (Johnny Depp) and Doug Penhall go undercover into the 'KKK Gang', which is feared for their crimes. It quickly becomes clear that many of the members follow their leader Lancer unconditionally, and he encourages them to commit crimes. Brian is the only one who sometimes questions Lancer's instructions, whom they can win over.